Medicare Part D Drug Coverage List

According to the Centers for Medicare & Medicaid Services (CMS) 2026 Part D formulary data, this list covers 6,046 drugs across Medicare Part D plans, sorted by how broadly each is covered. Under the Inflation Reduction Act, Part D out-of-pocket costs are capped at $2,000 a year in 2026; see our methodology for how coverage breadth is calculated.

Coverage varies by plan and geography. Verify drug coverage with your specific plan before making decisions.

Overview Browse Drugs Part D Plans Rankings

Drug Name	Plans Covering	Coverage %	Avg Tier	PA %	2023 Benes
0.5 ML interferon beta-1a 0.044 MG/ML Prefilled Syringe [Rebif] interferon	201	4%	T4	73.9%	1,364
ceftolozane 1000 MG / tazobactam 500 MG Injection [Zerbaxa] ceftolozane	201	4%	T4	6.3%	967
24 HR bupropion hydrobromide 348 MG Extended Release Oral Tablet [Aplenzin] bupropion hydrobromide	199	3.9%	T4	0%	741
24 HR bupropion hydrobromide 522 MG Extended Release Oral Tablet [Aplenzin] bupropion hydrobromide	199	3.9%	T4	0%	741
tazarotene 0.5 MG/ML Topical Cream [Tazorac] tazarotene	198	3.9%	T4	66.7%	4,869
0.5 ML pegvaliase-pqpz 5 MG/ML Prefilled Syringe [Palynziq] pegvaliase-pqpz	198	3.9%	T4	95.5%	91
1 ML pegvaliase-pqpz 20 MG/ML Prefilled Syringe [Palynziq] pegvaliase-pqpz	198	3.9%	T4	95.5%	91
0.5 ML pegvaliase-pqpz 20 MG/ML Prefilled Syringe [Palynziq] pegvaliase-pqpz	198	3.9%	T4	95.5%	91
Twice-Daily deferiprone 1000 MG Oral Tablet [Ferriprox] Twice-Daily deferiprone	196	3.9%	T5	70%	40
{4 (ozanimod 0.23 MG Oral Capsule [Zeposia]) / 3 (ozanimod 0.46 MG Oral Capsule [Zeposia]) / 21 (ozanimod 0.92 MG Oral Capsule [Zeposia]) } Pack [Zeposia 28-Day Starter Kit] ozanimod	195	3.8%	T4	97.7%	1,034
metaxalone 800 MG Oral Tablet metaxalone	193	3.8%	T2	61.5%	24,167
delgocitinib 20 MG/ML Topical Cream [Anzupgo] delgocitinib	193	3.8%	T4	85.7%	-
{28 (alpelisib 200 MG Oral Tablet [Vijoice]) / 28 (alpelisib 50 MG Oral Tablet [Vijoice]) } Pack [Vijoice 250 MG 28 Day] alpelisib	192	3.8%	T4	97.3%	31
sofosbuvir 400 MG Oral Tablet [Sovaldi] sofosbuvir	192	3.8%	T4	83.3%	18
sofosbuvir 200 MG Oral Tablet [Sovaldi] sofosbuvir	191	3.8%	T4	80%	18
sofosbuvir 150 MG Oral Pellet [Sovaldi] sofosbuvir	191	3.8%	T4	80%	18
sofosbuvir 200 MG Oral Pellet [Sovaldi] sofosbuvir	191	3.8%	T4	80%	18
Abuse-Deterrent 12 HR oxycodone hydrochloride 10 MG Extended Release Oral Tablet [Oxycontin] Abuse-Deterrent	189	3.7%	T2	58.8%	65,061
Abuse-Deterrent 12 HR oxycodone hydrochloride 15 MG Extended Release Oral Tablet [Oxycontin] Abuse-Deterrent	189	3.7%	T2	58.8%	65,061
Abuse-Deterrent 12 HR oxycodone hydrochloride 20 MG Extended Release Oral Tablet [Oxycontin] Abuse-Deterrent	189	3.7%	T2	58.8%	65,061
Abuse-Deterrent 12 HR oxycodone hydrochloride 30 MG Extended Release Oral Tablet [Oxycontin] Abuse-Deterrent	189	3.7%	T2	58.8%	65,061
Abuse-Deterrent 12 HR oxycodone hydrochloride 40 MG Extended Release Oral Tablet [Oxycontin] Abuse-Deterrent	189	3.7%	T2	58.8%	65,061
Abuse-Deterrent 12 HR oxycodone hydrochloride 60 MG Extended Release Oral Tablet [Oxycontin] Abuse-Deterrent	189	3.7%	T2	58.8%	65,061
Abuse-Deterrent 12 HR oxycodone hydrochloride 80 MG Extended Release Oral Tablet [Oxycontin] Abuse-Deterrent	189	3.7%	T2	58.8%	65,061
Timothy grass pollen extract 2800 BAU Sublingual Tablet [Grastek] Timothy grass pollen extract	189	3.7%	T3	58.3%	170
deferiprone 1000 MG Oral Tablet [Ferriprox] deferiprone	188	3.7%	T5	62.5%	198
estazolam 1 MG Oral Tablet estazolam	186	3.7%	T2	23.5%	13,042
estazolam 2 MG Oral Tablet estazolam	186	3.7%	T2	23.5%	13,042
oxymorphone hydrochloride 5 MG Oral Tablet oxymorphone hydrochloride	186	3.7%	T3	0%	3,885
oxymorphone hydrochloride 10 MG Oral Tablet oxymorphone hydrochloride	186	3.7%	T3	0%	3,885
glutamine 5000 MG Powder for Oral Solution [Endari] glutamine	186	3.7%	T5	92.3%	557
levonorgestrel 0.000729 MG/HR Intrauterine System [Kyleena] levonorgestrel	185	3.7%	T3	0%	650
citalopram 30 MG Oral Capsule citalopram	183	3.6%	T3	0%	1,454,397
probenecid 500 MG / sulopenem etzadroxil 500 MG Oral Tablet [Orlynvah] probenecid	183	3.6%	T4	50%	15,132
1.5 ML brodalumab 140 MG/ML Prefilled Syringe [Siliq] brodalumab	183	3.6%	T4	94.1%	218
24 HR alprazolam 0.5 MG Extended Release Oral Tablet alprazolam	181	3.6%	T2	7.4%	-
24 HR alprazolam 1 MG Extended Release Oral Tablet alprazolam	181	3.6%	T2	7.4%	-
betamethasone 0.5 MG/ML / calcipotriene 0.05 MG/ML Topical Lotion betamethasone	180	3.6%	T4	30.8%	407,711
lomitapide 5 MG Oral Capsule [Juxtapid] lomitapide	179	3.5%	T4	100%	14
lomitapide 10 MG Oral Capsule [Juxtapid] lomitapide	179	3.5%	T4	100%	14
lomitapide 20 MG Oral Capsule [Juxtapid] lomitapide	179	3.5%	T4	100%	14
lomitapide 30 MG Oral Capsule [Juxtapid] lomitapide	179	3.5%	T4	100%	14
1 ML ixekizumab 80 MG/ML Auto-Injector [Taltz] ixekizumab	179	3.5%	T4	92%	-
1 ML ixekizumab 80 MG/ML Prefilled Syringe [Taltz] ixekizumab	179	3.5%	T4	92%	-
azelastine hydrochloride 0.137 MG/ACTUAT / fluticasone propionate 0.05 MG/ACTUAT Metered Dose Nasal Spray azelastine hydrochloride	177	3.5%	T3	0%	1,194,948
24 HR alprazolam 2 MG Extended Release Oral Tablet alprazolam	177	3.5%	T2	7.7%	-
24 HR alprazolam 3 MG Extended Release Oral Tablet alprazolam	177	3.5%	T2	7.7%	-
lenalidomide 2.5 MG Oral Capsule [Revlimid] lenalidomide	176	3.5%	T4	100%	36,967
lenalidomide 5 MG Oral Capsule [Revlimid] lenalidomide	176	3.5%	T4	100%	36,967
lenalidomide 10 MG Oral Capsule [Revlimid] lenalidomide	176	3.5%	T4	100%	36,967
lenalidomide 15 MG Oral Capsule [Revlimid] lenalidomide	176	3.5%	T4	100%	36,967
lenalidomide 20 MG Oral Capsule [Revlimid] lenalidomide	176	3.5%	T4	100%	36,967
lenalidomide 25 MG Oral Capsule [Revlimid] lenalidomide	176	3.5%	T4	100%	36,967
anidulafungin 50 MG Injection [Eraxis] anidulafungin	176	3.5%	T3	42.1%	146
Once-Daily gabapentin 450 MG Oral Tablet Once-Daily gabapentin	176	3.5%	T2	92.6%	-
Once-Daily gabapentin 750 MG Oral Tablet Once-Daily gabapentin	176	3.5%	T2	92.6%	-
Once-Daily gabapentin 900 MG Oral Tablet Once-Daily gabapentin	176	3.5%	T2	92.6%	-
cyclobenzaprine hydrochloride 7.5 MG Oral Tablet cyclobenzaprine hydrochloride	175	3.5%	T3	37.5%	2,458,292
crinecerfont 50 MG Oral Capsule [Crenessity] crinecerfont	175	3.5%	T4	87.5%	-
crinecerfont 100 MG Oral Capsule [Crenessity] crinecerfont	175	3.5%	T4	87.5%	-
treprostinil 0.016 MG Inhalation Powder [Tyvaso] treprostinil	174	3.4%	T4	89.5%	3,017
treprostinil 0.032 MG Inhalation Powder [Tyvaso] treprostinil	174	3.4%	T4	89.5%	3,017
treprostinil 0.048 MG Inhalation Powder [Tyvaso] treprostinil	174	3.4%	T4	89.5%	3,017
treprostinil 0.064 MG Inhalation Powder [Tyvaso] treprostinil	174	3.4%	T4	89.5%	3,017
{112 (treprostinil 0.016 MG Inhalation Powder [Tyvaso]) / 112 (treprostinil 0.032 MG Inhalation Powder [Tyvaso]) / 28 (treprostinil 0.048 MG Inhalation Powder [Tyvaso]) } Pack [Tyvaso 16-32-48 MCG Titration Pack] treprostinil	174	3.4%	T4	89.5%	-
crinecerfont 50 MG/ML Oral Solution [Crenessity] crinecerfont	174	3.4%	T4	86.7%	-
clindamycin 100 MG Vaginal Insert [Cleocin] clindamycin	173	3.4%	T4	0%	8,722
{10 (cladribine 10 MG Oral Tablet [Mavenclad]) } Pack [Mavenclad 10 Tablet Pack] cladribine	172	3.4%	T4	94.1%	1,130
{4 (cladribine 10 MG Oral Tablet [Mavenclad]) } Pack [Mavenclad 4 Tablet Pack] cladribine	172	3.4%	T4	94.1%	1,130
{5 (cladribine 10 MG Oral Tablet [Mavenclad]) } Pack [Mavenclad 5 Tablet Pack] cladribine	172	3.4%	T4	94.1%	1,130
{6 (cladribine 10 MG Oral Tablet [Mavenclad]) } Pack [Mavenclad 6 Tablet Pack] cladribine	172	3.4%	T4	94.1%	1,130
{7 (cladribine 10 MG Oral Tablet [Mavenclad]) } Pack [Mavenclad 7 Tablet Pack] cladribine	172	3.4%	T4	94.1%	1,130
{8 (cladribine 10 MG Oral Tablet [Mavenclad]) } Pack [Mavenclad 8 Tablet Pack] cladribine	172	3.4%	T4	94.1%	1,130
{9 (cladribine 10 MG Oral Tablet [Mavenclad]) } Pack [Mavenclad 9 Tablet Pack] cladribine	172	3.4%	T4	94.1%	1,130
ruxolitinib 15 MG/ML Topical Cream [Opzelura] ruxolitinib	171	3.4%	T5	77.8%	14,085
clocortolone 1 MG/ML Topical Cream clocortolone	171	3.4%	T4	0%	577
glycerol phenylbutyrate 1100 MG/ML Oral Solution glycerol phenylbutyrate	171	3.4%	T4	94.9%	87
sertraline 150 MG Oral Capsule sertraline	170	3.4%	T3	0%	3,041,276
sertraline 200 MG Oral Capsule sertraline	170	3.4%	T3	0%	3,041,276
flurazepam hydrochloride 30 MG Oral Capsule flurazepam hydrochloride	170	3.4%	T2	5%	23
elafibranor 80 MG Oral Tablet [Iqirvo] elafibranor	170	3.4%	T4	86.7%	-
tretinoin 0.0008 MG/MG Topical Gel tretinoin	169	3.3%	T4	100%	91,688
methotrexate 5 MG Oral Tablet [Trexall] methotrexate	169	3.3%	T3	25%	84
methotrexate 7.5 MG Oral Tablet [Trexall] methotrexate	169	3.3%	T3	25%	84
methotrexate 10 MG Oral Tablet [Trexall] methotrexate	169	3.3%	T3	25%	84
methotrexate 15 MG Oral Tablet [Trexall] methotrexate	169	3.3%	T3	25%	84
naldemedine 0.2 MG Oral Tablet [Symproic] naldemedine	166	3.3%	T3	16.7%	5,113
40/60 Release 24 HR methylphenidate hydrochloride 10 MG Extended Release Oral Capsule	166	3.3%	T2	0%	-
40/60 Release 24 HR methylphenidate hydrochloride 30 MG Extended Release Oral Capsule	166	3.3%	T2	0%	-
40/60 Release 24 HR methylphenidate hydrochloride 40 MG Extended Release Oral Capsule	166	3.3%	T2	0%	-
0.25 ML ixekizumab 80 MG/ML Prefilled Syringe [Taltz] ixekizumab	164	3.2%	T4	91.3%	-
0.5 ML ixekizumab 80 MG/ML Prefilled Syringe [Taltz] ixekizumab	164	3.2%	T4	91.3%	-
24 HR nitroglycerin 0.3 MG/HR Transdermal System [Nitro-Dur] nitroglycerin	163	3.2%	T3	0%	451
24 HR nitroglycerin 0.8 MG/HR Transdermal System [Nitro-Dur] nitroglycerin	163	3.2%	T3	0%	451
methsuximide 300 MG Oral Capsule [Celontin] methsuximide	163	3.2%	T3	0%	217
azelaic acid 200 MG/ML Topical Cream [Azelex] azelaic acid	161	3.2%	T3	0%	37,203
tiopronin 100 MG Delayed Release Oral Tablet [Venxxiva] tiopronin	161	3.2%	T4	25%	261
tiopronin 300 MG Delayed Release Oral Tablet [Venxxiva] tiopronin	161	3.2%	T4	25%	261
maralixibat 9.5 MG/ML Oral Solution [Livmarli] maralixibat	161	3.2%	T4	100%	-
maralixibat 19 MG/ML Oral Solution [Livmarli] maralixibat	161	3.2%	T4	100%	-

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Source: CMS Quarterly Prescription Drug Plan Formulary PUF 2026. 6,046 drugs with RXCUI identifiers from NLM RxNorm. Coverage percentages based on 0 active Part D plans.

Compiled by Plainmedicare Editorial, Health Insurance Editorial Team