Medicare Part D Drug Coverage List

According to the Centers for Medicare & Medicaid Services (CMS) 2026 Part D formulary data, this list covers 6,046 drugs across Medicare Part D plans, sorted by how broadly each is covered. Under the Inflation Reduction Act, Part D out-of-pocket costs are capped at $2,000 a year in 2026; see our methodology for how coverage breadth is calculated.

Coverage varies by plan and geography. Verify drug coverage with your specific plan before making decisions.

Overview Browse Drugs Part D Plans Rankings

Drug Name	Plans Covering	Coverage %	Avg Tier	PA %	2023 Benes
acyclovir 50 MG/ML Topical Cream acyclovir	160	3.2%	T2	6.5%	670,065
istradefylline 20 MG Oral Tablet [Nourianz] istradefylline	160	3.2%	T4	46.2%	3,546
istradefylline 40 MG Oral Tablet [Nourianz] istradefylline	160	3.2%	T4	46.2%	3,546
40/60 Release 24 HR methylphenidate hydrochloride 15 MG Extended Release Oral Capsule	160	3.2%	T2	0%	-
40/60 Release 24 HR methylphenidate hydrochloride 20 MG Extended Release Oral Capsule	160	3.2%	T2	0%	-
40/60 Release 24 HR methylphenidate hydrochloride 50 MG Extended Release Oral Capsule	160	3.2%	T2	0%	-
40/60 Release 24 HR methylphenidate hydrochloride 60 MG Extended Release Oral Capsule	160	3.2%	T2	0%	-
crinecerfont 25 MG Oral Capsule [Crenessity] crinecerfont	160	3.2%	T4	85.7%	-
tramadol hydrochloride 100 MG Oral Tablet tramadol hydrochloride	159	3.1%	T2	4.3%	3,884,717
prucalopride 1 MG Oral Tablet prucalopride	158	3.1%	T3	3.8%	19,413
prucalopride 2 MG Oral Tablet prucalopride	158	3.1%	T3	3.8%	19,413
aspirin 325 MG / butalbital 50 MG / caffeine 40 MG / codeine phosphate 30 MG Oral Capsule aspirin	156	3.1%	T2	60.7%	22,634
leniolisib 70 MG Oral Tablet [Joenja] leniolisib	156	3.1%	T4	100%	-
metformin hydrochloride 750 MG Oral Tablet metformin hydrochloride	155	3.1%	T3	1.9%	5,918,026
meclofenamate 50 MG Oral Capsule meclofenamate	154	3%	T2	0%	153
meclofenamate 100 MG Oral Capsule meclofenamate	154	3%	T2	0%	153
20 ML pegcetacoplan 54 MG/ML Injection [Empaveli] pegcetacoplan	154	3%	T4	100%	68
mifepristone 300 MG Oral Tablet [Korlym] mifepristone	153	3%	T4	100%	1,059
cyclosporine 1 MG/ML Ophthalmic Suspension [Verkazia] cyclosporine	152	3%	T5	75%	492,479
1.2 ML garadacimab-gxii 167 MG/ML Auto-Injector [Andembry] garadacimab-gxii	152	3%	T4	83.3%	-
{14 (migalastat 123 MG Oral Capsule [Galafold]) } Pack [Galafold 28 Day Wallet] migalastat	151	3%	T4	100%	114
deuruxolitinib 8 MG Oral Tablet [Leqselvi] deuruxolitinib	150	3%	T4	94.4%	-
cyclosporine 0.9 MG/ML Ophthalmic Solution [Cequa] cyclosporine	149	2.9%	T3	20%	492,479
12 HR zileuton 600 MG Extended Release Oral Tablet zileuton	149	2.9%	T4	45.5%	-
sitagliptin 25 MG Oral Tablet sitagliptin	148	2.9%	T2	0%	168,527
sitagliptin 50 MG Oral Tablet sitagliptin	148	2.9%	T2	0%	168,527
sitagliptin 100 MG Oral Tablet sitagliptin	148	2.9%	T2	0%	168,527
crofelemer 125 MG Delayed Release Oral Tablet [Mytesi] crofelemer	148	2.9%	T4	61.5%	379
24 HR diazoxide choline 25 MG Extended Release Oral Tablet [Vykat] diazoxide choline	147	2.9%	T4	80%	-
24 HR diazoxide choline 75 MG Extended Release Oral Tablet [Vykat] diazoxide choline	147	2.9%	T4	80%	-
24 HR diazoxide choline 150 MG Extended Release Oral Tablet [Vykat] diazoxide choline	147	2.9%	T4	80%	-
ursodiol 200 MG Oral Capsule ursodiol	146	2.9%	T4	5.8%	102,032
ursodiol 400 MG Oral Capsule ursodiol	146	2.9%	T4	5.8%	102,032
pitolisant 4.45 MG Oral Tablet [Wakix] pitolisant	146	2.9%	T5	85.7%	1,235
pitolisant 17.8 MG Oral Tablet [Wakix] pitolisant	146	2.9%	T5	85.7%	1,235
corticotropin 80 UNT/ML Injectable Solution [Acthar] corticotropin	146	2.9%	T4	100%	942
hydrocortisone butyrate 1 MG/ML Topical Lotion hydrocortisone butyrate	145	2.9%	T2	0%	6,139
1 ML corticotropin 80 UNT/ML Prefilled Syringe [Acthar] corticotropin	145	2.9%	T4	100%	942
0.5 ML corticotropin 80 UNT/ML Prefilled Syringe [Acthar] corticotropin	145	2.9%	T4	100%	942
sparsentan 400 MG Oral Tablet [Filspari] sparsentan	144	2.8%	T4	97%	112
0.98 ML teriparatide 0.3 MG/ML Pen Injector [Yorvipath] teriparatide	143	2.8%	T4	100%	109,257
methyltestosterone 10 MG Oral Tablet [Methitest] methyltestosterone	143	2.8%	T5	11.1%	20
0.56 ML teriparatide 0.3 MG/ML Pen Injector [Yorvipath] teriparatide	143	2.8%	T4	100%	-
1.4 ML teriparatide 0.3 MG/ML Pen Injector [Yorvipath] teriparatide	143	2.8%	T4	100%	-
nitisinone 10 MG Oral Tablet [Nityr] nitisinone	143	2.8%	T5	100%	-
nitisinone 2 MG Oral Tablet [Nityr] nitisinone	143	2.8%	T5	100%	-
nitisinone 5 MG Oral Tablet [Nityr] nitisinone	143	2.8%	T5	100%	-
0.5 ML leuprolide acetate 60 MG/ML Prefilled Syringe [Vabrinty] leuprolide acetate	143	2.8%	T5	57.1%	-
0.375 ML leuprolide acetate 120 MG/ML Prefilled Syringe [Vabrinty] leuprolide acetate	143	2.8%	T5	57.1%	-
hydroxyurea 100 MG/ML Oral Solution [Xromi] hydroxyurea	142	2.8%	T4	25%	102,368
podofilox 0.005 MG/MG Topical Gel podofilox	142	2.8%	T3	0%	3,737
amcinonide 1 MG/ML Topical Cream amcinonide	142	2.8%	T3	0%	30
0.2 ML adalimumab-atto 100 MG/ML Prefilled Syringe [Amjevita] adalimumab-atto	142	2.8%	T4	66.7%	-
0.4 ML adalimumab-atto 100 MG/ML Prefilled Syringe [Amjevita] adalimumab-atto	142	2.8%	T4	66.7%	-
0.8 ML adalimumab-atto 100 MG/ML Auto-Injector [Amjevita] adalimumab-atto	142	2.8%	T4	66.7%	-
0.4 ML adalimumab-atto 100 MG/ML Auto-Injector [Amjevita] adalimumab-atto	142	2.8%	T4	66.7%	-
1 ML spesolimab-sbzo 150 MG/ML Prefilled Syringe [Spevigo] spesolimab-sbzo	141	2.8%	T4	100%	20
2 ML spesolimab-sbzo 150 MG/ML Prefilled Syringe [Spevigo] spesolimab-sbzo	141	2.8%	T4	100%	20
estradiol 1 MG / norethindrone acetate 0.5 MG / relugolix 40 MG Oral Tablet [Myfembree] estradiol	140	2.8%	T4	97.6%	1,289,816
sparsentan 200 MG Oral Tablet [Filspari] sparsentan	140	2.8%	T4	100%	112
nitroglycerin 0.4 MG Sublingual Tablet [Nitrostat] nitroglycerin	139	2.7%	T3	0%	1,348,161
carisoprodol 250 MG Oral Tablet carisoprodol	139	2.7%	T2	65%	62,766
24 HR hydromorphone hydrochloride 8 MG Extended Release Oral Tablet hydromorphone hydrochloride	139	2.7%	T3	76.9%	-
24 HR hydromorphone hydrochloride 12 MG Extended Release Oral Tablet hydromorphone hydrochloride	139	2.7%	T3	76.9%	-
24 HR hydromorphone hydrochloride 16 MG Extended Release Oral Tablet hydromorphone hydrochloride	139	2.7%	T3	76.9%	-
baclofen 2 MG/ML Oral Solution baclofen	138	2.7%	T2	7.7%	1,303,677
selegiline hydrochloride 1.25 MG Disintegrating Oral Tablet [Zelapar] selegiline hydrochloride	138	2.7%	T5	0%	877
1.5 ML fremanezumab-vfrm 150 MG/ML Auto-Injector [Ajovy] fremanezumab-vfrm	138	2.7%	T3	62.5%	-
1.5 ML fremanezumab-vfrm 150 MG/ML Prefilled Syringe [Ajovy] fremanezumab-vfrm	138	2.7%	T3	62.5%	-
0.375 ML leuprolide acetate 60 MG/ML Prefilled Syringe [Vabrinty] leuprolide acetate	135	2.7%	T5	40%	-
nitroglycerin 0.6 MG Sublingual Tablet [Nitrostat] nitroglycerin	134	2.6%	T2	0%	1,348,161
nitroglycerin 0.3 MG Sublingual Tablet [Nitrostat] nitroglycerin	133	2.6%	T2	0%	1,348,161
levoketoconazole 150 MG Oral Tablet [Recorlev] levoketoconazole	132	2.6%	T4	87.1%	85
{21 (lamotrigine 25 MG Disintegrating Oral Tablet) / 7 (lamotrigine 50 MG Disintegrating Oral Tablet) } Pack lamotrigine	132	2.6%	T3	0%	-
{14 (lamotrigine 100 MG Disintegrating Oral Tablet) / 42 (lamotrigine 50 MG Disintegrating Oral Tablet) } Pack lamotrigine	132	2.6%	T3	0%	-
tapinarof 10 MG/ML Topical Cream [Vtama] tapinarof	131	2.6%	T4	40%	6,158
somatropin 6 MG Cartridge [Humatrope] somatropin	130	2.6%	T4	100%	1,572
somatropin 12 MG Cartridge [Humatrope] somatropin	130	2.6%	T4	100%	1,572
somatropin 24 MG Cartridge [Humatrope] somatropin	130	2.6%	T4	100%	1,572
acetaminophen 300 MG / butalbital 50 MG / caffeine 40 MG / codeine phosphate 30 MG Oral Capsule acetaminophen	130	2.6%	T3	46.7%	156
dicyclomine hydrochloride 40 MG Oral Tablet dicyclomine hydrochloride	129	2.5%	T4	0%	887,927
aspirin 325 MG / butalbital 50 MG / caffeine 40 MG / codeine phosphate 30 MG Oral Capsule [Ascomp] aspirin	129	2.5%	T3	33.3%	22,634
abrocitinib 50 MG Oral Tablet [Cibinqo] abrocitinib	128	2.5%	T4	100%	347
abrocitinib 200 MG Oral Tablet [Cibinqo] abrocitinib	128	2.5%	T4	100%	347
24 HR hydromorphone hydrochloride 32 MG Extended Release Oral Tablet hydromorphone hydrochloride	127	2.5%	T3	80%	-
0.2 ML adalimumab-atto 50 MG/ML Prefilled Syringe [Amjevita] adalimumab-atto	127	2.5%	T4	50%	-
calcium oxybate 234 MG/ML / magnesium oxybate 96 MG/ML / potassium oxybate 130 MG/ML / sodium oxybate 40 MG/ML Oral Solution [Xywav] calcium oxybate	125	2.5%	T4	100%	108,459
20 ML apomorphine hydrochloride 4.9 MG/ML Cartridge [Onapgo] apomorphine hydrochloride	125	2.5%	T4	100%	-
levorphanol tartrate 2 MG Oral Tablet levorphanol tartrate	124	2.4%	T3	12.5%	657
levorphanol tartrate 3 MG Oral Tablet levorphanol tartrate	124	2.4%	T3	12.5%	657
acetaminophen 325 MG / butalbital 50 MG Oral Tablet [Tencon] acetaminophen	124	2.4%	T2	50%	156
0.5 ML ustekinumab-auub 90 MG/ML Injection [Wezlana] ustekinumab-auub	124	2.4%	T4	100%	-
0.5 ML ustekinumab-auub 90 MG/ML Prefilled Syringe [Wezlana] ustekinumab-auub	124	2.4%	T4	100%	-
1 ML ustekinumab-auub 90 MG/ML Prefilled Syringe [Wezlana] ustekinumab-auub	124	2.4%	T4	100%	-
posaconazole 300 MG Powder for Oral Suspension [Noxafil] posaconazole	122	2.4%	T4	100%	8,353
gabapentin 100 MG Oral Tablet [Gabarone] gabapentin	121	2.4%	T3	0%	7,553,448
gabapentin 400 MG Oral Tablet [Gabarone] gabapentin	121	2.4%	T3	0%	7,553,448
baclofen 5 MG/ML Oral Suspension baclofen	121	2.4%	T4	0%	1,303,677
desoximetasone 2.5 MG/ML Topical Spray desoximetasone	121	2.4%	T3	0%	27,754
nitrofurantoin 10 MG/ML Oral Suspension nitrofurantoin	121	2.4%	T4	0%	1,444

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Source: CMS Quarterly Prescription Drug Plan Formulary PUF 2026. 6,046 drugs with RXCUI identifiers from NLM RxNorm. Coverage percentages based on 0 active Part D plans.

Compiled by Plainmedicare Editorial, Health Insurance Editorial Team