Medicare Part D Drug Coverage List

According to the Centers for Medicare & Medicaid Services (CMS) 2026 Part D formulary data, this list covers 6,046 drugs across Medicare Part D plans, sorted by how broadly each is covered. Under the Inflation Reduction Act, Part D out-of-pocket costs are capped at $2,000 a year in 2026; see our methodology for how coverage breadth is calculated.

Coverage varies by plan and geography. Verify drug coverage with your specific plan before making decisions.

Overview Browse Drugs Part D Plans Rankings

Drug Name	Plans Covering	Coverage %	Avg Tier	PA %	2023 Benes
eluxadoline 100 MG Oral Tablet [Viberzi] eluxadoline	519	10.2%	T4	55.9%	7,023
acoramidis 356 MG Oral Tablet [Attruby] acoramidis	517	10.2%	T4	97.8%	-
desoximetasone 0.0005 MG/MG Topical Gel desoximetasone	514	10.1%	T3	0%	27,754
revefenacin 0.0583 MG/ML Inhalation Solution [Yupelri] revefenacin	513	10.1%	T5	100%	1,274
0.8 ML adalimumab-aaty 100 MG/ML Auto-Injector [Yuflyma] adalimumab-aaty	513	10.1%	T4	100%	-
{3 (0.8 ML adalimumab-aaty 100 MG/ML Auto-Injector [Yuflyma]) } Pack [Yuflyma Auto-Injector 80 MG/0.8 ML Starter Package for Crohn's Disease, Ulcerative Colitis or Hidradenitis Suppurativa] adalimumab-aaty	513	10.1%	T4	100%	-
0.2 ML adalimumab-aaty 100 MG/ML Prefilled Syringe [Yuflyma] adalimumab-aaty	513	10.1%	T4	100%	-
0.4 ML adalimumab-aaty 100 MG/ML Prefilled Syringe [Yuflyma] adalimumab-aaty	513	10.1%	T4	100%	-
0.4 ML adalimumab-aaty 100 MG/ML Auto-Injector [Yuflyma] adalimumab-aaty	513	10.1%	T4	100%	-
1 ML denosumab-bnht 60 MG/ML Prefilled Syringe [Conexxence] denosumab-bnht	503	9.9%	T2	0%	-
amoxicillin 25 MG/ML / clavulanate 6.25 MG/ML Oral Suspension [Augmentin] amoxicillin	502	9.9%	T3	0%	6,202,496
tirbanibulin 0.01 MG/MG Topical Ointment [Klisyri] tirbanibulin	501	9.9%	T4	12.3%	1,900
Once-Daily gabapentin 600 MG Oral Tablet Once-Daily gabapentin	498	9.8%	T3	84.8%	-
diclofenac sodium 20 MG/ML Topical Solution diclofenac sodium	497	9.8%	T4	72%	3,196,668
tobramycin 0.003 MG/MG Ophthalmic Ointment [Tobrex] tobramycin	490	9.7%	T4	0%	195,319
3 ML insulin glargine 300 UNT/ML Pen Injector insulin glargine	488	9.6%	T3	1.9%	-
1.5 ML insulin glargine 300 UNT/ML Pen Injector insulin glargine	488	9.6%	T3	1.9%	-
lidocaine 0.018 MG/MG Medicated Patch [ZTlido] lidocaine	483	9.5%	T3	93.9%	481,042
Once-Daily gabapentin 300 MG Oral Tablet Once-Daily gabapentin	482	9.5%	T3	87.5%	-
adapalene 1 MG/ML Topical Cream adapalene	481	9.5%	T3	17.8%	4,155
nitisinone 4 MG/ML Oral Suspension [Orfadin] nitisinone	480	9.5%	T4	66.7%	-
24 HR desvenlafaxine 50 MG Extended Release Oral Tablet desvenlafaxine	477	9.4%	T3	3.4%	-
24 HR desvenlafaxine 100 MG Extended Release Oral Tablet desvenlafaxine	477	9.4%	T3	3.4%	-
0.8 ML adalimumab-adbm 50 MG/ML Prefilled Syringe [Cyltezo] adalimumab-adbm	476	9.4%	T4	100%	-
0.8 ML adalimumab-adbm 50 MG/ML Auto-Injector [Cyltezo] adalimumab-adbm	476	9.4%	T4	100%	-
0.2 ML adalimumab-adbm 50 MG/ML Prefilled Syringe [Cyltezo] adalimumab-adbm	476	9.4%	T4	100%	-
0.4 ML adalimumab-adbm 50 MG/ML Prefilled Syringe [Cyltezo] adalimumab-adbm	476	9.4%	T4	100%	-
0.4 ML adalimumab-adbm 100 MG/ML Prefilled Syringe [Cyltezo] adalimumab-adbm	476	9.4%	T4	100%	-
0.4 ML adalimumab-adbm 100 MG/ML Auto-Injector [Cyltezo] adalimumab-adbm	476	9.4%	T4	100%	-
250 MG estradiol 0.001 MG/MG Topical Gel estradiol	474	9.4%	T4	0%	-
sargramostim 0.25 MG/ML Injectable Solution [Leukine] sargramostim	473	9.3%	T4	74.1%	113
Sensor 3 ML insulin lispro-aabc 100 UNT/ML Pen Injector [Lyumjev] Sensor	472	9.3%	T3	1.9%	3,723
500 MG estradiol 0.001 MG/MG Topical Gel estradiol	470	9.3%	T4	0%	-
1000 MG estradiol 0.001 MG/MG Topical Gel estradiol	470	9.3%	T4	0%	-
750 MG estradiol 0.001 MG/MG Topical Gel estradiol	470	9.3%	T4	0%	-
1250 MG estradiol 0.001 MG/MG Topical Gel estradiol	464	9.2%	T4	0%	-
0.14 ML risperidone 357 MG/ML Prefilled Syringe [Uzedy] risperidone	463	9.1%	T4	21.3%	1,164
0.21 ML risperidone 357 MG/ML Prefilled Syringe [Uzedy] risperidone	463	9.1%	T4	21.3%	1,164
0.28 ML risperidone 357 MG/ML Prefilled Syringe [Uzedy] risperidone	463	9.1%	T4	21.3%	1,164
0.35 ML risperidone 357 MG/ML Prefilled Syringe [Uzedy] risperidone	463	9.1%	T4	21.3%	1,164
0.42 ML risperidone 357 MG/ML Prefilled Syringe [Uzedy] risperidone	463	9.1%	T4	21.3%	1,164
0.56 ML risperidone 357 MG/ML Prefilled Syringe [Uzedy] risperidone	463	9.1%	T4	21.3%	1,164
0.7 ML risperidone 357 MG/ML Prefilled Syringe [Uzedy] risperidone	463	9.1%	T4	21.3%	1,164
0.68 ML vedolizumab 159 MG/ML Auto-Injector [Entyvio] vedolizumab	462	9.1%	T5	98.5%	2,238
griseofulvin 165 MG Oral Tablet griseofulvin	461	9.1%	T3	0%	1,743
{8 (estradiol 0.004 MG Vaginal Insert [Imvexxy]) } Pack [Imvexxy 4 MCG Maintenance Pack] estradiol	457	9%	T3	10.8%	8,850
{18 (estradiol 0.004 MG Vaginal Insert [Imvexxy]) } Pack [Imvexxy 4 MCG Starter Pack] estradiol	457	9%	T3	10.8%	8,850
{8 (estradiol 0.01 MG Vaginal Insert [Imvexxy]) } Pack [Imvexxy 10 MCG Maintenance Pack] estradiol	457	9%	T3	10.8%	8,850
{18 (estradiol 0.01 MG Vaginal Insert [Imvexxy]) } Pack [Imvexxy 10 MCG Starter Pack] estradiol	457	9%	T3	10.8%	8,850
risdiplam 0.75 MG/ML Oral Solution [Evrysdi] risdiplam	447	8.8%	T4	98.8%	424
PMDD fluoxetine 10 MG Oral Tablet PMDD fluoxetine	442	8.7%	T2	0%	-
PMDD fluoxetine 20 MG Oral Tablet PMDD fluoxetine	442	8.7%	T2	0%	-
acetaminophen 300 MG / butalbital 50 MG / caffeine 40 MG Oral Capsule acetaminophen	441	8.7%	T3	57.8%	156
Emollient clobetasol propionate 0.5 MG/ML Topical Foam Emollient clobetasol propionate	436	8.6%	T3	0%	-
bromfenac 0.7 MG/ML Ophthalmic Solution [Prolensa] bromfenac	435	8.6%	T3	0%	144,112
penicillamine 250 MG Oral Capsule penicillamine	429	8.5%	T4	17.9%	162
0.9 ML tocilizumab 180 MG/ML Prefilled Syringe [Actemra] tocilizumab	426	8.4%	T4	100%	109,257
0.9 ML tocilizumab 180 MG/ML Auto-Injector [Actemra] tocilizumab	426	8.4%	T4	100%	109,257
{7 (siponimod 0.25 MG Oral Tablet [Mayzent]) } Pack [Mayzent 1 MG Starter Pack] siponimod	425	8.4%	T3	72.4%	928
desoximetasone 0.0005 MG/MG Topical Ointment desoximetasone	422	8.3%	T3	0%	27,754
siponimod 0.25 MG Oral Tablet [Mayzent] siponimod	422	8.3%	T4	73.6%	928
siponimod 2 MG Oral Tablet [Mayzent] siponimod	422	8.3%	T4	73.6%	928
siponimod 1 MG Oral Tablet [Mayzent] siponimod	422	8.3%	T4	73.6%	928
{12 (siponimod 0.25 MG Oral Tablet [Mayzent]) } Pack [Mayzent 2 MG Starter Pack] siponimod	421	8.3%	T4	73.3%	928
24 HR venlafaxine 225 MG Extended Release Oral Tablet venlafaxine	419	8.3%	T2	0%	-
24 HR venlafaxine 75 MG Extended Release Oral Tablet venlafaxine	417	8.2%	T2	0%	-
fluoxetine 25 MG / olanzapine 6 MG Oral Capsule fluoxetine	416	8.2%	T3	7.7%	1,427,221
fluoxetine 50 MG / olanzapine 6 MG Oral Capsule fluoxetine	416	8.2%	T3	7.7%	1,427,221
fluoxetine 25 MG / olanzapine 12 MG Oral Capsule fluoxetine	416	8.2%	T3	7.7%	1,427,221
fluoxetine 50 MG / olanzapine 12 MG Oral Capsule fluoxetine	416	8.2%	T3	7.7%	1,427,221
fluoxetine 25 MG / olanzapine 3 MG Oral Capsule fluoxetine	416	8.2%	T3	7.7%	1,427,221
azithromycin 10 MG/ML Ophthalmic Solution [AzaSite] azithromycin	415	8.2%	T3	0%	5,970,026
betaxolol 2.5 MG/ML Ophthalmic Suspension [Betoptic S] betaxolol	410	8.1%	T3	2.8%	7,458
piperacillin 2000 MG / tazobactam 250 MG Injection [Zosyn] piperacillin	408	8.1%	T3	0%	22,422
24 HR venlafaxine 37.5 MG Extended Release Oral Tablet venlafaxine	406	8%	T2	0%	-
itraconazole 10 MG/ML Oral Solution itraconazole	404	8%	T3	17.5%	13,522
caffeine 100 MG / ergotamine tartrate 2 MG Rectal Suppository [Migergot] caffeine	403	8%	T4	0%	96
methylnaltrexone bromide 150 MG Oral Tablet [Relistor] methylnaltrexone bromide	400	7.9%	T4	60.9%	15,141
2 ML tralokinumab-ldrm 150 MG/ML Auto-Injector [Adbry] tralokinumab-ldrm	400	7.9%	T4	98.2%	1,712
tobramycin 75 MG/ML Inhalation Solution tobramycin	399	7.9%	T4	98.5%	195,319
24 HR venlafaxine 150 MG Extended Release Oral Tablet venlafaxine	399	7.9%	T2	0%	-
imipramine pamoate 75 MG Oral Capsule imipramine pamoate	395	7.8%	T2	27.7%	1,234
imipramine pamoate 100 MG Oral Capsule imipramine pamoate	395	7.8%	T2	27.7%	1,234
imipramine pamoate 125 MG Oral Capsule imipramine pamoate	395	7.8%	T2	27.7%	1,234
imipramine pamoate 150 MG Oral Capsule imipramine pamoate	395	7.8%	T2	27.7%	1,234
{24 (ethinyl estradiol 0.02 MG / norethindrone acetate 1 MG Oral Capsule) / 4 (ferrous fumarate 75 MG Oral Capsule) } Pack [Gemmily 28 Day] ethinyl estradiol	394	7.8%	T2	0%	-
12 HR orphenadrine citrate 100 MG Extended Release Oral Tablet orphenadrine citrate	391	7.7%	T2	35.7%	-
1 ML tralokinumab-ldrm 150 MG/ML Prefilled Syringe [Adbry] tralokinumab-ldrm	388	7.7%	T4	98.2%	1,712
diflorasone diacetate 0.0005 MG/MG Topical Ointment diflorasone diacetate	380	7.5%	T3	0%	6,653
ensifentrine 1.2 MG/ML Inhalation Suspension [Ohtuvayre] ensifentrine	375	7.4%	T4	100%	-
Osmotic 24 HR metformin hydrochloride 1000 MG Extended Release Oral Tablet Osmotic	371	7.3%	T2	5%	-
acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG Oral Capsule acetaminophen	370	7.3%	T3	58.2%	156
betamethasone valerate 1.2 MG/ML Topical Foam betamethasone valerate	369	7.3%	T3	0%	145,618
methylprednisolone 2 MG Oral Tablet [Medrol] methylprednisolone	366	7.2%	T3	41.7%	4,135,771
flavoxate hydrochloride 100 MG Oral Tablet flavoxate hydrochloride	366	7.2%	T2	0%	1,990
tretinoin 0.0004 MG/MG Topical Gel tretinoin	363	7.2%	T3	73.3%	91,688
azelaic acid 150 MG/ML Topical Foam [Finacea] azelaic acid	363	7.2%	T4	0%	37,203
24 HR metformin hydrochloride 1000 MG / saxagliptin 2.5 MG Extended Release Oral Tablet metformin hydrochloride	359	7.1%	T2	0%	-
24 HR metformin hydrochloride 1000 MG / saxagliptin 5 MG Extended Release Oral Tablet metformin hydrochloride	359	7.1%	T2	0%	-
24 HR metformin hydrochloride 500 MG / saxagliptin 5 MG Extended Release Oral Tablet metformin hydrochloride	359	7.1%	T2	0%	-

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Source: CMS Quarterly Prescription Drug Plan Formulary PUF 2026. 6,046 drugs with RXCUI identifiers from NLM RxNorm. Coverage percentages based on 0 active Part D plans.

Compiled by Plainmedicare Editorial, Health Insurance Editorial Team