Medicare Part D drugs starting with P
159 drugs start with P; 79 of them are on at least 90% of 2026 Part D formularies. Part D spending was highest for Pomalyst in 2024: $2.2 billion, what plans and patients paid at the pharmacy before rebates.
Which drugs start with P?
| Drug | Plans covering | Usual tier | Medicare spending, 2024 |
|---|---|---|---|
| Pacerone (amiodarone hydrochloride) | 78.5% | Tier 2 | $4 million |
| Paliperidone | 100% | Tier 4 | $78 million |
| Palsonify (paltusotine) | 0.4% | Tier 5 | no 2024 match |
| Palynziq (pegvaliase-pqpz) | 3.9% | Tier 5 | $25 million |
| Pancreaze (amylase / lipase / protease) | 0.6% | Tier 3 | $12 million |
| Panretin (alitretinoin) | 100% | Tier 5 | $1 million |
| Pantoprazole | 100% | Tier 1 | $321 million |
| Panzyga (immune globulin intravenous, human) | 15% | Tier 5 | $158 million |
| Paricalcitol | 96.9% | Tier 4 | $3 million |
| Parnate (tranylcypromine) | under 0.1% | Tier 1 | $476 thousand |
| Paroxetine hydrochloride | 100% | Tier 1 | $54 million |
| Paroxetine mesylate | 5.3% | Tier 3 | $626 thousand |
| Paxil (paroxetine hydrochloride) | under 0.1% | Tier 1 | $4 million |
| Paxlovid (nirmatrelvir) | 100% | Tier 2 | $90 million |
| Pazopanib | 100% | Tier 5 | $42 million |
| Pediarix (DTaP-HepB-IPV vaccine) | 100% | Tier 1 | $16 thousand |
| PedvaxHIB (Hib vaccine) | 100% | Tier 1 | $38 thousand |
| Pegasys (peginterferon alfa-2a) | 100% | Tier 5 | $31 million |
| Pemazyre (pemigatinib) | 100% | Tier 5 | $30 million |
| Penbraya (meningococcal ABCWY vaccine) | 100% | Tier 1 | $28 thousand |
| Penciclovir | 10.4% | Tier 4 | $3 million |
| Penicillamine | 100% | Tier 5 | $8 million |
| Penicillin g potassium | 97.8% | Tier 4 | $1 million |
| Penicillin g sodium | 89.3% | Tier 4 | $99 thousand |
| Penicillin v potassium | 100% | Tier 1 | $3 million |
| Penmenvy (meningococcal ABCWY vaccine) | 100% | Tier 1 | no 2024 match |
| Pentacel (DTaP-IPV-Hib vaccine) | 100% | Tier 1 | $94 thousand |
| Pentam (pentamidine isethionate) | under 0.1% | Tier 1 | no 2024 match |
| Pentamidine isethionate | 100% | Tier 4 | $8 thousand |
| Pentasa (mesalamine) | 22.1% | Tier 4 | $30 million |
| Pentoxifylline | 100% | Tier 2 | $12 million |
| Pepcid (famotidine) | under 0.1% | Tier 1 | $795 thousand |
| Perampanel | 84% | Tier 4 | no 2024 match |
| Percocet (acetaminophen / oxycodone hydrochloride) | 0.2% | Tier 2 | $60 million |
| Perforomist (formoterol fumarate) | 4.7% | Tier 5 | $459 thousand |
| Perindopril erbumine | 96% | Tier 1 | $1 million |
| Periogard (chlorhexidine gluconate) | 96.3% | Tier 1 | $23 thousand |
| Permethrin | 100% | Tier 3 | $10 million |
| Perphenazine | 100% | Tier 4 | $11 million |
| Perseris (risperidone) | 25.8% | Tier 5 | $48 million |
Show the other 119 drugs
| Drug | Plans covering | Usual tier | Medicare spending, 2024 |
|---|---|---|---|
| Pertzye (amylase / lipase / protease) | 0.1% | Tier 4 | $7 million |
| Pheburane (sodium phenylbutyrate) | 1.7% | Tier 5 | $488 thousand |
| Phenelzine | 100% | Tier 3 | $1 million |
| Phenobarbital | 100% | Tier 2 | $12 million |
| Phenoxybenzamine hydrochloride | 12.9% | Tier 5 | $2 million |
| Phenylephrine hydrochloride / promethazine hydrochloride | 0.3% | Tier 2 | $28 thousand |
| Phenytek (phenytoin sodium) | 68.1% | Tier 2 | $1 million |
| Phenytoin | 100% | Tier 2 | $4 million |
| Phenytoin sodium | 100% | Tier 2 | $19 million |
| Phexx (citric acid / lactic acid / potassium bitartrate) | 0.3% | Tier 4 | no 2024 match |
| Phexxi (citric acid / lactic acid / potassium bitartrate) | 0.3% | Tier 4 | $82 thousand |
| Phospholine Iodide (echothiophate iodide) | 16.6% | Tier 5 | $1 million |
| Phyrago (dasatinib) | 23.1% | Tier 5 | no 2024 match |
| Pifeltro (doravirine) | 100% | Tier 5 | $79 million |
| Pilocarpine hydrochloride | 100% | Tier 3 | $21 million |
| Pimecrolimus | 94.7% | Tier 4 | $17 million |
| Pimozide | 100% | Tier 4 | $1 million |
| Pimtrea (desogestrel / ethinyl estradiol) | 95.2% | Tier 2 | $7 thousand |
| Pindolol | 76.9% | Tier 3 | $2 million |
| Pioglitazone | 100% | Tier 1 | $42 million |
| Piperacillin / tazobactam | 100% | Tier 4 | $14 million |
| Piqray (alpelisib) | 100% | Tier 5 | $110 million |
| Pirfenidone | 100% | Tier 5 | $128 million |
| Piroxicam | 89.4% | Tier 3 | $6 million |
| Pitavastatin calcium | 32.2% | Tier 1 | $37 million |
| Plaquenil (hydroxychloroquine sulfate) | under 0.1% | Tier 1 | $6 million |
| Plasmalyte A (magnesium chloride and 4 more ingredients) | 21.4% | Tier 4 | no 2024 match |
| Plavix (clopidogrel) | under 0.1% | Tier 1 | $6 million |
| Plegridy (peginterferon beta-1a) | 11.6% | Tier 5 | $37 million |
| Plenamine (alanine and 16 more ingredients) | 86.3% | Tier 4 | $74 thousand |
| Plenvu (ascorbic acid and 4 more ingredients) | 33.6% | Tier 4 | $8 million |
| Pmdd fluoxetine | 25.8% | Tier 2 | no 2024 match |
| Podofilox | 100% | Tier 2 | $613 thousand |
| Polyethylene glycol / potassium chloride / sodium bicarbonate / sodium chloride | 100% | Tier 2 | no 2024 match |
| Polyethylene glycol and 4 more ingredients | 99.1% | Tier 2 | no 2024 match |
| Polymyxin b | 55.7% | Tier 4 | $22 thousand |
| Polymyxin b / trimethoprim | 100% | Tier 1 | $4 million |
| Pomalidomide | 92.1% | Tier 5 | no 2024 match |
| Pomalyst (pomalidomide) | 49.9% | Tier 5 | $2.2 billion |
| Ponvory (ponesimod) | 0.3% | Tier 5 | $6 million |
| Portia (ethinyl estradiol / levonorgestrel) | 97.5% | Tier 2 | $59 thousand |
| Posaconazole | 100% | Tier 5 | $51 million |
| Potassium chloride | 100% | Tier 2 | $291 million |
| Potassium chloride / sodium chloride | 89.9% | Tier 4 | no 2024 match |
| Potassium citrate | 100% | Tier 2 | no 2024 match |
| Praluent (alirocumab) | 10.9% | Tier 3 | $341 million |
| Pramipexole dihydrochloride | 100% | Tier 2 | no 2024 match |
| Pramosone (hydrocortisone acetate / pramoxine hydrochloride) | 0.4% | Tier 4 | $83 thousand |
| Prasugrel | 98.4% | Tier 2 | $27 million |
| Pravastatin sodium | 100% | Tier 1 | $127 million |
| Praziquantel | 100% | Tier 4 | $1 million |
| Prazosin | 100% | Tier 2 | $25 million |
| Pred Forte (prednisolone acetate) | under 0.1% | Tier 1 | $959 thousand |
| Pred Mild (prednisolone) | 20.1% | Tier 4 | $735 thousand |
| Prednisolone | 100% | Tier 2 | $3 million |
| Prednisolone acetate | 100% | Tier 3 | $155 million |
| Prednisolone sodium phosphate / sulfacetamide sodium | 99.6% | Tier 2 | $28 thousand |
| Prednisone | 100% | Tier 1 | $65 million |
| Pregabalin | 100% | Tier 3 | $201 million |
| Premarin (estrogens, conjugated) | 90% | Tier 3 | $255 million |
| PremaSol (alanine and 18 more ingredients) | 83.9% | Tier 5 | $418 thousand |
| Premphase | 35.9% | Tier 3 | $279 thousand |
| Prempro (estrogens, conjugated / medroxyprogesterone acetate) | 54% | Tier 3 | $38 million |
| Pretomanid | 22.4% | Tier 4 | $55 thousand |
| Prevacid (lansoprazole) | under 0.1% | Tier 1 | $9 million |
| Prevalite (sugar-free cholestyramine resin) | 98.2% | Tier 4 | $4 million |
| Prevymis (letermovir) | 100% | Tier 5 | $120 million |
| Prezcobix (cobicistat / darunavir) | 100% | Tier 5 | $255 million |
| Prezista (darunavir) | 100% | Tier 4 | $25 million |
| Priftin (rifapentine) | 100% | Tier 4 | $552 thousand |
| Primaquine phosphate | 100% | Tier 4 | $27 thousand |
| Primaxin (cilastatin / imipenem) | 0.3% | Tier 4 | $19 thousand |
| Primidone | 100% | Tier 2 | $34 million |
| Priorix (MMR vaccine) | 100% | Tier 1 | $230 thousand |
| Pristiq (desvenlafaxine succinate) | under 0.1% | Tier 1 | $6 million |
| Privigen (immunoglobulin g, human) | 36% | Tier 5 | $494 million |
| ProAir (albuterol) | 6.4% | Tier 3 | $5 million |
| Probenecid | 100% | Tier 2 | $5 million |
| Procardia (nifedipine) | under 0.1% | Tier 1 | $979 thousand |
| ProCentra (dextroamphetamine sulfate) | 0.2% | Tier 2 | no 2024 match |
| Prochlorperazine | 100% | Tier 2 | $12 million |
| Procrit (epoetin alfa) | 67.7% | Tier 3 | $157 million |
| Procto-Med (hydrocortisone) | 97% | Tier 2 | no 2024 match |
| Proctofoam-HC (hydrocortisone acetate / pramoxine hydrochloride) | 4.6% | Tier 1 | $3 million |
| Proctosol (hydrocortisone) | 81% | Tier 2 | no 2024 match |
| Proctozone HC (hydrocortisone) | 83.3% | Tier 2 | $919 thousand |
| Procysbi (cysteamine) | 0.8% | Tier 5 | $38 million |
| Progesterone | 96% | Tier 2 | $25 million |
| Proglycem (diazoxide) | under 0.1% | Tier 1 | $166 thousand |
| Prograf (tacrolimus) | 100% | Tier 4 | $4 million |
| Prolastin (alpha 1-proteinase inhibitor, human) | 79.6% | Tier 5 | $229 million |
| Prolensa (bromfenac) | 8.6% | Tier 3 | $44 million |
| Prolia (denosumab) | 43.7% | Tier 4 | $772 million |
| Promacta (eltrombopag) | 20.3% | Tier 5 | $672 million |
| Promethazine hydrochloride | 100% | Tier 1 | $13 million |
| Promethegan (promethazine hydrochloride) | 33.7% | Tier 4 | $2 million |
| Propafenone hydrochloride | 100% | Tier 2 | $24 million |
| Propranolol hydrochloride | 100% | Tier 2 | $101 million |
| Propylthiouracil | 100% | Tier 2 | $2 million |
| ProQuad (MMRV vaccine) | 100% | Tier 1 | $10 thousand |
| Proscar (finasteride) | under 0.1% | Tier 1 | $406 thousand |
| Prosol (alanine and 16 more ingredients) | 75.3% | Tier 4 | $17 million |
| Protonix (pantoprazole) | under 0.1% | Tier 1 | $11 million |
| Protriptyline hydrochloride | 100% | Tier 4 | $2 million |
| Provera (medroxyprogesterone acetate) | under 0.1% | Tier 1 | $35 thousand |
| Provigil (modafinil) | 0.1% | Tier 5 | $13 million |
| Prozac (fluoxetine) | under 0.1% | Tier 1 | $16 million |
| Prucalopride | 4.3% | Tier 2 | no 2024 match |
| Prudoxin (doxepin hydrochloride) | 0.1% | Tier 1 | no 2024 match |
| Pulmicort (budesonide) | 8.7% | Tier 3 | $281 thousand |
| Pulmozyme (dornase alfa) | 99.7% | Tier 5 | $2 million |
| Purixan (mercaptopurine) | 38% | Tier 5 | $62 thousand |
| Pylera | 0.6% | Tier 4 | $168 thousand |
| Pyquvi (deflazacort) | 12.8% | Tier 5 | no 2024 match |
| Pyrazinamide | 100% | Tier 4 | $600 thousand |
| Pyridostigmine bromide | 100% | Tier 3 | $30 million |
| Pyrimethamine | 100% | Tier 5 | $8 million |
| Pyrukynd (mitapivat) | 28.8% | Tier 5 | $6 million |
| Pyzchiva (ustekinumab-ttwe) | 33.5% | Tier 3 | no 2024 match |
Source: CMS Part D formulary file, 2026 second quarter; CMS Medicare Part D Spending by Drug, 2024.
What else should you check?
- Every drug, by letterAnd the 20 that cost Medicare most
- Stand-alone drug plans for 2027Premiums and deductibles
- Part D in 2027What changes for drug plans