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Is Clinimix E (alanine and 20 more ingredients) covered by Medicare Part D?

1,344 of 5,052 Medicare Part D plan offerings (26.6%) list Clinimix E on their 2026 formulary, most often on tier 4; 90.9% of the formularies that cover it require prior authorization.

Plans that cover it
26.6%
1,344 of 5,052 offerings; the median drug: 76%
Usual tier
Tier 4
from tier 1 to tier 4
Prior authorization
90.9%
of formularies that cover it; the median drug: 1%
Quantity limits
0%
of formularies that cover it; the median drug: 30%

Source: CMS Part D formulary file, 2026 second quarter: the formularies in use in 2026. A plan's 2027 formulary can differ; check your own plan's coverage in Medicare Plan Finder.

What does it cost under Part D in 2027?

Your yearly cap in 2027
Out-of-pocket spending on covered Part D drugs stops at $2,400 in 2027 ($2,100 in 2026); after that, you pay nothing for covered drugs for the rest of the year.
The deductible
A plan's drug deductible is at most $700 in 2027 ($615 in 2026); many plans charge less or none.

Source: CMS, Announcement of calendar year 2027 Part D parameters; Medicare.gov, “How much does Medicare drug coverage cost?” (read Oct. 7, 2026).

How much does Medicare spend on it?

Part D spending by year

2020$112 thousand
2021$59 thousand
2022$104 thousand
2023$101 thousand
2024 (latest)$77 thousand

Source: CMS Medicare Part D Spending by Drug, 2020 to 2024 (published June 2026). Row used: Clinimix E (Aa 4.25 % No.1/D5W/Lytes No.39), Clinimix E (Aa 4.25% No.1/D10w/Lytes No.39), Clinimix E (Aa 5 % No.6/D15w/Lytes No.23), Clinimix E (Aa 5 % No.6/D20w/Lytes No.23), Clinimix E (Amino Ac 8 %/D14w/Electrolytes).

Which forms and strengths are counted?

  • alanine 10.4 mg/ml / arginine 5.75 mg/ml / calcium chloride 0.004 meq/ml / dibasic potassium phosphate 2.61 mg/ml / glucose 150 mg/ml / glycine 5.15 mg/ml / histidine 2.4 mg/ml / isoleucine 3 mg/ml / leucine 3.65 mg/ml / lysine 2.9 mg/ml / magnesium chloride 0.01 meq/ml / methionine 2 mg/ml / phenylalanine 2.8 mg/ml / proline 3.4 mg/ml / serine 2.5 mg/ml / sodium acetate trihydrate 3.4 mg/ml / sodium chloride 0.01 meq/ml / threonine 2.1 mg/ml / tryptophan 0.9 mg/ml / tyrosine 0.2 mg/ml / valine 2.9 mg/ml injectable solution
  • alanine 10.4 mg/ml / arginine 5.75 mg/ml / calcium chloride 0.004 meq/ml / dibasic potassium phosphate 2.61 mg/ml / glucose 200 mg/ml / glycine 5.15 mg/ml / histidine 2.4 mg/ml / isoleucine 3 mg/ml / leucine 3.65 mg/ml / lysine 2.9 mg/ml / magnesium chloride 0.01 meq/ml / methionine 2 mg/ml / phenylalanine 2.8 mg/ml / proline 3.4 mg/ml / serine 2.5 mg/ml / sodium acetate trihydrate 3.4 mg/ml / sodium chloride 0.01 meq/ml / threonine 2.1 mg/ml / tryptophan 0.9 mg/ml / tyrosine 0.2 mg/ml / valine 2.9 mg/ml injectable solution
  • alanine 5.7 mg/ml / arginine 3.16 mg/ml / calcium chloride 0.004 meq/ml / dibasic potassium phosphate 2.61 mg/ml / glucose 50 mg/ml / glycine 2.83 mg/ml / histidine 1.32 mg/ml / isoleucine 1.65 mg/ml / leucine 2.01 mg/ml / lysine 1.59 mg/ml / magnesium chloride 0.01 meq/ml / methionine 1.1 mg/ml / phenylalanine 1.54 mg/ml / proline 1.87 mg/ml / serine 1.38 mg/ml / sodium acetate trihydrate 2.17 mg/ml / sodium chloride 0.02 meq/ml / threonine 1.16 mg/ml / tryptophan 0.5 mg/ml / tyrosine 0.11 mg/ml / valine 1.6 mg/ml injectable solution
  • alanine 8.8 mg/ml / arginine 4.89 mg/ml / calcium chloride 0.004 meq/ml / dibasic potassium phosphate 2.61 mg/ml / glucose 100 mg/ml / glycine 4.38 mg/ml / histidine 2.04 mg/ml / isoleucine 2.55 mg/ml / leucine 3.11 mg/ml / lysine 2.47 mg/ml / magnesium chloride 0.01 meq/ml / methionine 1.7 mg/ml / phenylalanine 2.38 mg/ml / proline 2.89 mg/ml / serine 2.13 mg/ml / sodium acetate trihydrate 2.97 mg/ml / sodium chloride 0.013 meq/ml / threonine 1.79 mg/ml / tryptophan 0.77 mg/ml / tyrosine 0.17 mg/ml / valine 2.47 mg/ml injectable solution
  • alanine 8.8 mg/ml / arginine 4.89 mg/ml / calcium chloride 0.004 meq/ml / dibasic potassium phosphate 2.61 mg/ml / glucose 50 mg/ml / glycine 4.38 mg/ml / histidine 2.04 mg/ml / isoleucine 2.55 mg/ml / leucine 3.11 mg/ml / lysine 2.47 mg/ml / magnesium chloride 0.01 meq/ml / methionine 1.7 mg/ml / phenylalanine 2.38 mg/ml / proline 2.89 mg/ml / serine 2.13 mg/ml / sodium acetate trihydrate 2.97 mg/ml / sodium chloride 0.013 meq/ml / threonine 1.79 mg/ml / tryptophan 0.77 mg/ml / tyrosine 0.17 mg/ml / valine 2.47 mg/ml injectable solution

What else should you check?

Data, not medical advice. Coverage is the share of plan formularies listing the drug; your plan's formulary, tier and pharmacy decide what you pay.