0.5 ML interferon beta-1a 0.088 MG/ML Prefilled Syringe [Rebif]
interferon
RxCUI: 758027
What the CMS Formulary Data Shows for 0.5 ML interferon beta-1a 0.088 MG/ML Prefilled Syringe [Rebif]
Per the CMS 2026 Part D formulary file, 0.5 ML interferon beta-1a 0.088 MG/ML Prefilled Syringe [Rebif] (RxNorm concept RXCUI 758027, generic name interferon) appears on 47 distinct formulary files spanning 209 Medicare Part D plan offerings - 4.1% of enrollable Part D products, selective placement; verify formulary inclusion before enrolling. Tier placement ranges from Tier 1 to Tier 5, with a cross-plan average of Tier 4.3.
Real-world access to 0.5 ML interferon beta-1a 0.088 MG/ML Prefilled Syringe [Rebif] depends on utilization management as much as tier placement: 72.3% of covering formularies require prior authorization. 8.5% require step therapy. 51.1% apply quantity limits.
Historical spending context from the CMS Medicare Part D Drug Spending Dashboard shows 1,364 Part D beneficiaries filled 0.5 ML interferon beta-1a 0.088 MG/ML Prefilled Syringe [Rebif] in 2023, with total plan-and-beneficiary spending of $131,300,521 and an average per-beneficiary annual cost of $96,261.38. The plan-by-plan detail below lists exactly which PDP and MA-PD contracts carry 0.5 ML interferon beta-1a 0.088 MG/ML Prefilled Syringe [Rebif] today.
Coverage Details
- Formularies covering
- 47
- Plans covering
- 209
- Coverage rate
- 4.1%
- Tier range
- Tier 1 – Tier 5
- Average tier
- Tier 4, Non-Preferred
Restrictions
- Prior authorization required
- 72.3% of formularies
- Step therapy required
- 8.5% of formularies
- Quantity limits
- 51.1% of formularies
2023 Medicare Spending
- Beneficiaries
- 1,364
- Total spending
- $131,300,521
- Avg per beneficiary
- $96,261.38
Tier Distribution Across Plans
Medicare Advantage Plans (MA-PD) Covering 0.5 ML interferon beta-1a 0.088 MG/ML Prefilled Syringe [Rebif]
100 Medicare Advantage plans with Part D drug coverage include this drug.
| Plan | Insurer | Tier | PA | Premium | States |
|---|---|---|---|---|---|
| SeniorCare Complete (HMO D-SNP) | SOUTH COUNTRY HEALTH ALLIANCE | T1 | Yes | $0 | MN |
| AbilityCare (HMO D-SNP) | SOUTH COUNTRY HEALTH ALLIANCE | T1 | Yes | $0 | MN |
| Alameda Alliance Wellness (HMO D-SNP) | ALAMEDA ALLIANCE FOR HEALTH | T1 | Yes | $0 | CA |
| Provider Partners Pennsylvania Community Plan (HMO I-SNP) | PROVIDER PARTNERS HEALTH PLAN OF PENNSYLVANIA, INC | T1 | Yes | $0 | PA |
| Provider Partners North Carolina Community Plan (HMO I-SNP) | PROVIDER PARTNERS HEALTH PLAN OF NORTH CAROLINA | T1 | Yes | $0 | NC |
| Provider Partners Indiana Community Plan (HMO I-SNP) | PROVIDER PARTNERS HEALTH PLAN OF INDIANA | T1 | Yes | $0 | IN |
| Provider Partners Maryland Community Plan (HMO I-SNP) | PROVIDER PARTNERS HEALTH PLAN, INC. | T1 | Yes | $0 | MD |
| Provider Partners Missouri Community Plan (HMO I-SNP) | PROVIDER PARTNERS HEALTH PLAN OF MISSOURI, INC. | T1 | Yes | $0 | MO |
| Community Care's Partnership Program (HMO D-SNP) | COMMUNITY CARE HEALTH PLAN, INC. | T1 | No | $0 | WI |
| Mass General Brigham SCO (HMO D-SNP) | MASS GENERAL BRIGHAM HEALTH PLAN, INC | T1 | No | $0 | MA |
| Mass General Brigham One Care (HMO D-SNP) | MASS GENERAL BRIGHAM HEALTH PLAN, INC | T1 | No | $0 | MA |
| Tufts Health One Care (HMO D-SNP) | TUFTS HEALTH PUBLIC PLANS, INC. | T1 | No | $0 | MA |
| Tufts Health One Care CW (HMO D-SNP) | TUFTS HEALTH PUBLIC PLANS, INC. | T1 | No | $0 | MA |
| Tufts Health Plan Senior Care Options (HMO D-SNP) | TUFTS ASSOCIATED HEALTH MAINTENANCE ORGANIZATION | T1 | No | $0 | MA |
| Tufts Health Plan Senior Care Options CW (HMO D-SNP) | TUFTS ASSOCIATED HEALTH MAINTENANCE ORGANIZATION | T1 | No | $0 | MA |
| Provider Partners Texas Advantage Plan (HMO I-SNP) | PROVIDER PARTNERS HEALTH PLAN OF TEXAS, INC. | T1 | Yes | $4.80 | TX |
| Provider Partners Illinois Advantage Plan (HMO I-SNP) | PROVIDER PARTNERS HEALTH PLAN OF ILLINOIS | T1 | Yes | $15.20 | IL |
| Provider Partners Maryland Advantage Plan (HMO I-SNP) | PROVIDER PARTNERS HEALTH PLAN, INC. | T1 | Yes | $31.20 | MD |
| Provider Partners Maryland Essential Plan (HMO I-SNP) | PROVIDER PARTNERS HEALTH PLAN, INC. | T1 | Yes | $31.20 | MD |
| Provider Partners Pennsylvania Advantage Plan (HMO I-SNP) | PROVIDER PARTNERS HEALTH PLAN OF PENNSYLVANIA, INC | T1 | Yes | $32.70 | PA |
| Provider Partners Pennsylvania Essential Plan (HMO I-SNP) | PROVIDER PARTNERS HEALTH PLAN OF PENNSYLVANIA, INC | T1 | Yes | $32.70 | PA |
| Provider Partners North Carolina Advantage Plan (HMO I-SNP) | PROVIDER PARTNERS HEALTH PLAN OF NORTH CAROLINA | T1 | Yes | $36.20 | NC |
| Provider Partners North Carolina Essential Plan (HMO I-SNP) | PROVIDER PARTNERS HEALTH PLAN OF NORTH CAROLINA | T1 | Yes | $36.20 | NC |
| Provider Partners Indiana Advantage Plan (HMO I-SNP) | PROVIDER PARTNERS HEALTH PLAN OF INDIANA | T1 | Yes | $38.40 | IN |
| Provider Partners Indiana Essential Plan (HMO I-SNP) | PROVIDER PARTNERS HEALTH PLAN OF INDIANA | T1 | Yes | $38.40 | IN |
| Provider Partners Kentucky Advantage Plan (HMO I-SNP) | PROVIDER PARTNERS HEALTH PLAN OF KENTUCKY | T1 | Yes | $38.40 | KY |
| Provider Partners Missouri Advantage Plan (HMO I-SNP) | PROVIDER PARTNERS HEALTH PLAN OF MISSOURI, INC. | T1 | Yes | $43.00 | MO |
| Provider Partners Missouri Essential Plan (HMO I-SNP) | PROVIDER PARTNERS HEALTH PLAN OF MISSOURI, INC. | T1 | Yes | $43.00 | MO |
| CalOptima Health OneCare Complete (HMO D-SNP) | ORANGE COUNTY HEALTH AUTHORITY | T2 | Yes | $0 | CA |
| Medicare BlueEssential (PPO) | EXCELLUS HEALTH PLAN, INC. | T5 | No | $0 | NY |
| Medicare BlueActive (PPO) | EXCELLUS HEALTH PLAN, INC. | T5 | No | $0 | NY |
| Medicare BlueVital (PPO) | EXCELLUS HEALTH PLAN, INC. | T5 | No | $0 | NY |
| Univera SeniorChoice Basic (HMO) | EXCELLUS HEALTH PLAN, INC. | T5 | No | $0 | NY |
| Univera SeniorChoice Extra (HMO) | EXCELLUS HEALTH PLAN, INC. | T5 | No | $0 | NY |
| Medicare Blue Choice Core (HMO) | EXCELLUS HEALTH PLAN, INC. | T5 | No | $0 | NY |
| Univera Medicare Dual (HMO D-SNP) | EXCELLUS HEALTH PLAN COMMUNITY CARE LLC | T5 | No | $0 | NY |
| Medicare Blue Dual (HMO D-SNP) | EXCELLUS HEALTH PLAN COMMUNITY CARE LLC | T5 | No | $0 | NY |
| Personal Choice 65 Achieve Rx (PPO) | QCC INSURANCE COMPANY | T5 | No | $0 | PA |
| Keystone 65 Focus Rx (HMO-POS) | KEYSTONE HEALTH PLAN EAST, INC. | T5 | No | $0 | PA |
| Keystone 65 Focus Rx (HMO-POS) | KEYSTONE HEALTH PLAN EAST, INC. | T5 | No | $0 | PA |
| Keystone 65 Basic Rx (HMO) | KEYSTONE HEALTH PLAN EAST, INC. | T5 | No | $0 | PA |
| AmeriHealth Medicare Core (PPO) | AMERIHEALTH INSURANCE COMPANY OF NEW JERSEY | T5 | No | $0 | NJ |
| AmeriHealth Medicare Ultimate (PPO) | AMERIHEALTH INSURANCE COMPANY OF NEW JERSEY | T5 | No | $0 | NJ |
| eternalHealth Forever (HMO) | ETERNALHEALTH, INC. | T5 | Yes | $0 | MA |
| eternalHealth Freedom (PPO) | ETERNALHEALTH, INC. | T5 | Yes | $0 | MA |
| eternalHealth Give Back (PPO) | ETERNALHEALTH, INC. | T5 | Yes | $0 | MA |
| eternalHealth Horizon (HMO) | ETERNALHEALTH OF ARIZONA INC | T5 | Yes | $0 | AZ |
| eternalHealth Grand Give Back (HMO) | ETERNALHEALTH OF ARIZONA INC | T5 | Yes | $0 | AZ |
| eternalHealth + Fry's Medicare Advantage (HMO) | ETERNALHEALTH OF ARIZONA INC | T5 | Yes | $0 | AZ |
| Senior Care Plus Essential plan (HMO) | HOMETOWN HEALTH PLAN, INC. | T5 | Yes | $0 | NV |
Frequently Asked Questions
Is 0.5 ML interferon beta-1a 0.088 MG/ML Prefilled Syringe [Rebif] covered by Medicare Part D?
Yes, 0.5 ML interferon beta-1a 0.088 MG/ML Prefilled Syringe [Rebif] is covered by 209 Medicare Part D plans (4.1% of all Part D formularies).
What tier is 0.5 ML interferon beta-1a 0.088 MG/ML Prefilled Syringe [Rebif] on Medicare Part D plans?
0.5 ML interferon beta-1a 0.088 MG/ML Prefilled Syringe [Rebif] averages Tier 4.3 across Part D plans, ranging from Tier 1 to Tier 5.
Does 0.5 ML interferon beta-1a 0.088 MG/ML Prefilled Syringe [Rebif] require prior authorization?
72.3% of Part D formularies require prior authorization for 0.5 ML interferon beta-1a 0.088 MG/ML Prefilled Syringe [Rebif]. Step therapy: 8.5%. Quantity limits: 51.1%.
How much does Medicare spend on 0.5 ML interferon beta-1a 0.088 MG/ML Prefilled Syringe [Rebif]?
In 2023, total Medicare Part D spending on 0.5 ML interferon beta-1a 0.088 MG/ML Prefilled Syringe [Rebif] was $131,300,521, covering 1,364 beneficiaries. The average spend per beneficiary was $96,261.38.
Read our methodology - how this data is sourced, computed, and verified.