Medicare Part D Drug Coverage List

According to the Centers for Medicare & Medicaid Services (CMS) 2026 Part D formulary data, this list covers 6,046 drugs across Medicare Part D plans, sorted by how broadly each is covered. Under the Inflation Reduction Act, Part D out-of-pocket costs are capped at $2,000 a year in 2026; see our methodology for how coverage breadth is calculated.

Coverage varies by plan and geography. Verify drug coverage with your specific plan before making decisions.

Overview Browse Drugs Part D Plans Rankings

Drug Name	Plans Covering	Coverage %	Avg Tier	PA %	2023 Benes
talazoparib 1 MG Oral Capsule [Talzenna] talazoparib	5,067	100%	T4	99.4%	234
methsuximide 300 MG Oral Capsule methsuximide	5,067	100%	T3	0.3%	217
procarbazine 50 MG Oral Capsule [Matulane] procarbazine	5,067	100%	T4	15.8%	213
pemigatinib 4.5 MG Oral Tablet [Pemazyre] pemigatinib	5,067	100%	T4	99.1%	207
pemigatinib 9 MG Oral Tablet [Pemazyre] pemigatinib	5,067	100%	T4	99.1%	207
pemigatinib 13.5 MG Oral Tablet [Pemazyre] pemigatinib	5,067	100%	T4	99.1%	207
tazemetostat 200 MG Oral Tablet [Tazverik] tazemetostat	5,067	100%	T4	99.4%	207
sulfadiazine 500 MG Oral Tablet sulfadiazine	5,067	100%	T3	0%	205
entrectinib 100 MG Oral Capsule [Rozlytrek] entrectinib	5,067	100%	T4	99.4%	205
entrectinib 200 MG Oral Capsule [Rozlytrek] entrectinib	5,067	100%	T4	99.4%	205
entrectinib 50 MG Oral Pellet [Rozlytrek] entrectinib	5,067	100%	T4	99.4%	205
cobimetinib 20 MG Oral Tablet [Cotellic] cobimetinib	5,067	100%	T4	99.4%	199
trimipramine 25 MG Oral Capsule trimipramine	5,067	100%	T3	4.8%	198
trimipramine 50 MG Oral Capsule trimipramine	5,067	100%	T3	4.8%	198
trimipramine 100 MG Oral Capsule trimipramine	5,067	100%	T3	4.8%	198
fosamprenavir 700 MG Oral Tablet fosamprenavir	5,067	100%	T4	0%	180
toremifene 60 MG Oral Tablet toremifene	5,067	100%	T4	24.2%	173
mitotane 500 MG Oral Tablet [Lysodren] mitotane	5,067	100%	T4	0.3%	173
fenfluramine 2.2 MG/ML Oral Solution [Fintepla] fenfluramine	5,067	100%	T4	97.9%	160
acetaminophen 325 MG / hydrocodone bitartrate 5 MG Oral Tablet acetaminophen	5,067	100%	T2	0.9%	156
acetaminophen 325 MG / hydrocodone bitartrate 10 MG Oral Tablet acetaminophen	5,067	100%	T2	0.9%	156
acetaminophen 300 MG / codeine phosphate 15 MG Oral Tablet acetaminophen	5,067	100%	T2	0.9%	156
acetaminophen 300 MG / codeine phosphate 30 MG Oral Tablet acetaminophen	5,067	100%	T2	0.9%	156
acetaminophen 325 MG / oxycodone hydrochloride 5 MG Oral Tablet acetaminophen	5,067	100%	T2	0.9%	156
acetaminophen 325 MG / oxycodone hydrochloride 7.5 MG Oral Tablet acetaminophen	5,067	100%	T2	0.9%	156
acetaminophen 325 MG / oxycodone hydrochloride 10 MG Oral Tablet acetaminophen	5,067	100%	T2	0.9%	156
acetaminophen 325 MG / hydrocodone bitartrate 7.5 MG Oral Tablet acetaminophen	5,067	100%	T2	0.9%	156
acetaminophen 300 MG / codeine phosphate 60 MG Oral Tablet acetaminophen	5,067	100%	T2	0.9%	156
cobicistat 150 MG / darunavir 800 MG Oral Tablet [Prezcobix] cobicistat	5,067	100%	T4	0%	149
cobicistat 150 MG / darunavir 800 MG / emtricitabine 200 MG / tenofovir alafenamide 10 MG Oral Tablet [Symtuza] cobicistat	5,067	100%	T4	0%	149
cobicistat 150 MG / elvitegravir 150 MG / emtricitabine 200 MG / tenofovir disoproxil fumarate 300 MG Oral Tablet [Stribild] cobicistat	5,067	100%	T4	0%	149
cobicistat 150 MG / elvitegravir 150 MG / emtricitabine 200 MG / tenofovir alafenamide 10 MG Oral Tablet [Genvoya] cobicistat	5,067	100%	T4	0%	149
duvelisib 15 MG Oral Capsule [Copiktra] duvelisib	5,067	100%	T4	99.1%	148
duvelisib 25 MG Oral Capsule [Copiktra] duvelisib	5,067	100%	T4	99.1%	148
fruquintinib 1 MG Oral Capsule [Fruzaqla] fruquintinib	5,067	100%	T4	99.1%	147
fruquintinib 5 MG Oral Capsule [Fruzaqla] fruquintinib	5,067	100%	T4	99.1%	147
larotrectinib 25 MG Oral Capsule [Vitrakvi] larotrectinib	5,067	100%	T4	99.4%	144
larotrectinib 100 MG Oral Capsule [Vitrakvi] larotrectinib	5,067	100%	T4	99.4%	144
larotrectinib 20 MG/ML Oral Solution [Vitrakvi] larotrectinib	5,067	100%	T4	99.4%	144
amphotericin B liposomal 50 MG Injection amphotericin B liposomal	5,067	100%	T4	98.5%	144
artemether 20 MG / lumefantrine 120 MG Oral Tablet [Coartem] artemether	5,067	100%	T3	0%	141
fecal microbiota spores, live-brpk 30000000 UNT Oral Capsule [Vowst] fecal microbiota spores, live-brpk	5,067	100%	T4	98.2%	131
pralsetinib 100 MG Oral Capsule [Gavreto] pralsetinib	5,067	100%	T4	99.4%	129
vigabatrin 500 MG Oral Tablet vigabatrin	5,067	100%	T4	77.6%	124
vigabatrin 500 MG Powder for Oral Solution vigabatrin	5,067	100%	T4	77.9%	124
idelalisib 100 MG Oral Tablet [Zydelig] idelalisib	5,067	100%	T4	99.4%	97
idelalisib 150 MG Oral Tablet [Zydelig] idelalisib	5,067	100%	T4	99.4%	97
pyrimethamine 25 MG Oral Tablet pyrimethamine	5,067	100%	T4	84.8%	95
{21 (futibatinib 4 MG Oral Tablet [Lytgobi]) } Pack [Lytgobi 12 MG Daily Dose] futibatinib	5,067	100%	T4	99.1%	94
{28 (futibatinib 4 MG Oral Tablet [Lytgobi]) } Pack [Lytgobi 16 MG Daily Dose] futibatinib	5,067	100%	T4	99.1%	94
{35 (futibatinib 4 MG Oral Tablet [Lytgobi]) } Pack [Lytgobi 20 MG Daily Dose] futibatinib	5,067	100%	T4	99.1%	94
selumetinib 10 MG Oral Capsule [Koselugo] selumetinib	5,067	100%	T4	99.1%	93
selumetinib 25 MG Oral Capsule [Koselugo] selumetinib	5,067	100%	T4	99.1%	93
gefitinib 250 MG Oral Tablet gefitinib	5,067	100%	T4	99.4%	90
0.5 ML acellular pertussis vaccine, inactivated 0.116 MG/ML / diphtheria toxoid vaccine, inactivated 50 UNT/ML / hepatitis B surface antigen vaccine 0.02 MG/ML / poliovirus vaccine inactivated, type 1 (Mahoney) 80 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 16 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 64 UNT/ML / tetanus toxoid vaccine, inactivated 20 UNT/ML Prefilled Syringe [PEDIARIX] acellular pertussis vaccine, inactivated	5,067	100%	T2	0%	90
methotrexate 2.5 MG Oral Tablet methotrexate	5,067	100%	T2	27%	84
nelfinavir 250 MG Oral Tablet [Viracept] nelfinavir	5,067	100%	T4	0%	81
nelfinavir 625 MG Oral Tablet [Viracept] nelfinavir	5,067	100%	T4	0%	81
0.5 ML acellular pertussis vaccine, inactivated 0.116 MG/ML / diphtheria toxoid vaccine, inactivated 50 UNT/ML / poliovirus vaccine inactivated, type 1 (Mahoney) 80 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 16 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 64 UNT/ML / tetanus toxoid vaccine, inactivated 20 UNT/ML Prefilled Syringe [Kinrix] acellular pertussis vaccine, inactivated	5,067	100%	T2	0%	80
isocarboxazid 10 MG Oral Tablet [Marplan] isocarboxazid	5,067	100%	T3	0.6%	73
olutasidenib 150 MG Oral Capsule [Rezlidhia] olutasidenib	5,067	100%	T4	99.4%	71
tipranavir 250 MG Oral Capsule [Aptivus] tipranavir	5,067	100%	T4	0%	65
glasdegib 25 MG Oral Tablet [Daurismo] glasdegib	5,067	100%	T4	99.1%	62
glasdegib 100 MG Oral Tablet [Daurismo] glasdegib	5,067	100%	T4	99.1%	62
vorinostat 100 MG Oral Capsule [Zolinza] vorinostat	5,067	100%	T4	81.5%	61
nilutamide 150 MG Oral Tablet nilutamide	5,067	100%	T4	11.5%	61
alitretinoin 0.001 MG/MG Topical Gel [Panretin] alitretinoin	5,067	100%	T4	66.7%	58
ceritinib 150 MG Oral Tablet [Zykadia] ceritinib	5,067	100%	T4	98.8%	56
capivasertib 160 MG Oral Tablet [Truqap] capivasertib	5,067	100%	T4	99.1%	56
capivasertib 200 MG Oral Tablet [Truqap] capivasertib	5,067	100%	T4	99.1%	56
0.25 ML tick-borne encephalitis purified antigen 0.0048 MG/ML Prefilled Syringe [Ticovac] tick-borne encephalitis purified antigen	5,067	100%	T2	0.3%	45
0.5 ML tick-borne encephalitis purified antigen 0.0048 MG/ML Prefilled Syringe [Ticovac] tick-borne encephalitis purified antigen	5,067	100%	T2	0.3%	45
{84 (cabozantinib 20 MG Oral Capsule [Cometriq]) / 28 (cabozantinib 80 MG Oral Capsule [Cometriq]) } Pack [Cometriq 140 MG Daily Dose Carton] cabozantinib	5,067	100%	T4	99.4%	43
{28 (cabozantinib 20 MG Oral Capsule [Cometriq]) / 28 (cabozantinib 80 MG Oral Capsule [Cometriq]) } Pack [Cometriq 100 MG Daily Dose Carton] cabozantinib	5,067	100%	T4	99.4%	43
{84 (cabozantinib 20 MG Oral Capsule [Cometriq]) } Pack [Cometriq 60 MG Daily Dose Carton] cabozantinib	5,067	100%	T4	99.4%	43
0.5 ML interferon gamma-1b 0.2 MG/ML Injection [Actimmune] interferon	5,067	100%	T4	93.6%	43
dacomitinib 15 MG Oral Tablet [Vizimpro] dacomitinib	5,067	100%	T4	99.4%	35
dacomitinib 30 MG Oral Tablet [Vizimpro] dacomitinib	5,067	100%	T4	99.4%	35
dacomitinib 45 MG Oral Tablet [Vizimpro] dacomitinib	5,067	100%	T4	99.4%	35
vandetanib 100 MG Oral Tablet [Caprelsa] vandetanib	5,067	100%	T4	98.5%	32
vandetanib 300 MG Oral Tablet [Caprelsa] vandetanib	5,067	100%	T4	98.5%	32
molindone hydrochloride 5 MG Oral Tablet molindone hydrochloride	5,067	100%	T3	14.5%	30
molindone hydrochloride 10 MG Oral Tablet molindone hydrochloride	5,067	100%	T3	14.5%	30
molindone hydrochloride 25 MG Oral Tablet molindone hydrochloride	5,067	100%	T3	14.5%	30
stiripentol 250 MG Oral Capsule [Diacomit] stiripentol	5,067	100%	T4	79.7%	25
stiripentol 500 MG Oral Capsule [Diacomit] stiripentol	5,067	100%	T4	79.7%	25
stiripentol 250 MG Powder for Oral Suspension [Diacomit] stiripentol	5,067	100%	T4	79.7%	25
stiripentol 500 MG Powder for Oral Suspension [Diacomit] stiripentol	5,067	100%	T4	79.7%	25
0.5 ML modified Vaccinia Ankara-Bavarian Nordic 198000000 UNT/ML Injection [Jynneos] modified Vaccinia Ankara-Bavarian Nordic	5,067	100%	T2	53%	24
quizartinib 17.7 MG Oral Tablet [Vanflyta] quizartinib	5,067	100%	T4	99.1%	24
quizartinib 26.5 MG Oral Tablet [Vanflyta] quizartinib	5,067	100%	T4	99.1%	24
miltefosine 50 MG Oral Capsule [Impavido] miltefosine	5,067	100%	T4	65.8%	24
0.5 ML peginterferon alfa-2a 0.36 MG/ML Prefilled Syringe [Pegasys] peginterferon	5,067	100%	T4	70.6%	24
0.5 ML measles virus vaccine live, Enders' attenuated Edmonston strain 2000 UNT/ML / mumps virus vaccine live, Jeryl Lynn strain 40000 UNT/ML / rubella virus vaccine live (Wistar RA 27-3 strain) 2000 UNT/ML / varicella-zoster virus vaccine live (Oka-Merck) strain 20000 UNT/ML Injection [ProQuad] measles virus vaccine live, Enders' attenuated Edmonston strain	5,067	100%	T2	0.6%	21
thioguanine 40 MG Oral Tablet [Tabloid] thioguanine	5,067	100%	T4	26.1%	21
pentamidine isethionate 300 MG Injection pentamidine isethionate	5,067	100%	T3	2.1%	20
metyrosine 250 MG Oral Capsule metyrosine	5,067	100%	T4	67%	20
pexidartinib 125 MG Oral Capsule [Turalio] pexidartinib	5,067	100%	T4	99.1%	19
flutamide 125 MG Oral Capsule [Eulexin] flutamide	5,067	100%	T4	13%	19
1 ML pasireotide 0.3 MG/ML Injection [Signifor] pasireotide	5,067	100%	T4	98.2%	18

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Source: CMS Quarterly Prescription Drug Plan Formulary PUF 2026. 6,046 drugs with RXCUI identifiers from NLM RxNorm. Coverage percentages based on 0 active Part D plans.

Compiled by Plainmedicare Editorial, Health Insurance Editorial Team